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CAS 10203-08-4
3,5-Dichlorobenzaldehyde3,5-dichlorobenzaldehyde
Codes: (Ia)409139-7-a, LIFI-011, (II)409139-8-a
Application context (from source-drug indications)
Transthyretin amyloidosisTafamidisHeart diseaseTafamidisDry eye diseaseLifitegrastDry eye syndromeLifitegrastGraft-versus-host diseaseLifitegrastDiabetic macular oedemaLifitegrastKeratoconjunctivitis siccaLifitegrastAllergic conjunctivitisLifitegrastAmyloid polyneuropathyTafamidis MeglumineTransthyretin amyloidosisTafamidis MeglumineAmyloidosisTafamidis MeglumineCardiomyopathyTafamidis MeglumineLight-chain (AL) amyloidosisTafamidis MeglumineFamilial amyloid neuropathyTafamidis Meglumine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tafamidis | Tier C — Watch / trade | - |
| Lifitegrast | Tier C — Watch / trade | - |
| Tafamidis Meglumine | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3,5-Dichlorobenzaldehyde→3,5-Dichlorobenzoic acid→2-Amino-5-methylphenol→1-Amino-2-hydroxy-4-ethylbenzene→2-Amino-5-butylphenol→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)-6-methyl-1,3-benzoxazole→2-(3,5-Dichlorophenyl)-6-ethyl-1,3-benzoxazole→6-Butyl-2-(3,5-dichlorophenyl)-1,3-benzoxazole→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→4-([(1E)-(3,5-Dichlorophenyl)methylene]amino)-3-hydroxybenzoic acid
(S)-2-amino-3-(3-bromophenyl)propanoic acid→(S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid→(S)-2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoic acid→(S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoate→(S)-benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride→5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid→(S)-benzyl 2-(5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate→(S)-benzyl 2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride→benzofuran-6-carboxylic acid→(S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate→3,5-dichlorobenzaldehyde→2-chloroethan-1-amine hydrochloride→2-chloro-N-(3,5-dichlorobenzyl)ethanamine→5,7-dichloro-1,2,3,4-tetrahydroisoquinoline→5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline→6-hydroxybenzofuran-3(2H)-one→6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one→benzofuran-6-ol→benzofuran-6-yl trifluoromethanesulfonate→methyl benzofuran-6-carboxylate
2-Hydroxy-4-methoxycarbonylaniline→Butyl 4-amino-3-hydroxybenzoate→tert-Butyl 4-amino-3-hydroxybenzoate→Phenyl 4-amino-3-hydroxybenzoate→3,5-Dichlorobenzaldehyde→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→tert-Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→Phenyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | benzofuran-6-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | methyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.