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CAS 1024120-52-2
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole
Codes: ITACI-026
Application context (from source-drug indications)
Diffuse large B-cell lymphomaItacitinibMyeloproliferative neoplasmItacitinibAcute lymphoblastic leukaemiaItacitinibAcute myeloid leukaemiaItacitinibChronic myelomonocytic leukaemiaItacitinib骨髓增生异常-骨髓增生性疾病Itacitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Itacitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl 3-(cyanomethylene)azetidine-1-carboxylate→4-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)-1H-pyrazole→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-one→1H-pyrazole→2-(azetidin-3-ylidene)acetonitrile hydrochloride→2-(1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-ylidene)acetonitrile→2-(1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile→4-bromo-1H-pyrazole→4-bromo-1-(1-ethoxyethyl)-1H-pyrazole→2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→pyrimidine-4,6-diol→4,6-dichloropyrimidine-5-carbaldehyde→4-amino-6-chloropyrimidine-5-carbaldehyde→(E)-6-chloro-5-(2-methoxyvinyl)pyrimidin-4-amine→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile
Intermediates available on this site
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