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CAS 1029052-74-1
5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine
Codes: PEXI-006
Application context (from source-drug indications)
Tenosynovial giant cell tumourPexidartinibPlexiform neurofibromaPexidartinibAcute lymphoblastic leukaemiaPexidartinibAcute promyelocytic leukaemiaPexidartinibSarcomaPexidartinibMelanomaPexidartinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pexidartinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-chloro-1H-pyrrolo[2,3-b]pyridine→5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-bromopyridin-2-amine→(6-aminopyridin-3-yl)(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine→6-(trifluoromethyl)nicotinaldehyde→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
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