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CAS 103129-82-4
3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Codes: (XV)109067-6-a, Levamlodipine Besylate-003
Application context (from source-drug indications)
HypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateHypertensionLevamlodipine BesylateAngina pectorisLevamlodipine BesylateEssential hypertensionLevamlodipine BesylateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionAmlodipine Camsylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Levamlodipine Besylate | Tier C — Watch / trade | - |
| Amlodipine Orotate | Tier C — Watch / trade | - |
| Amlodipine Camsylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-azidoethan-1-ol→2-Chloroacetic acid→2-(2-azidoethoxy)acetic acid→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Hydroxypropionitrile→2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid→(2S)-2-methoxy-2-phenylethan-1-ol→3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-azidoethan-1-ol→2-Chloroacetic acid→2-(2-azidoethoxy)acetic acid→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Hydroxypropionitrile→2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid→(2S)-2-methoxy-2-phenylethan-1-ol→3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine→Bis[3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate] (2S,3S)-2,3-dihydroxybutanedioic acid urea→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→(2S,3S)-2,3-Dihydroxybutanedioic acid 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (1/2)→(2R,3R)-2,3-Dihydroxybutanedioic acid 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (1/2)
2-azidoethan-1-ol→2-Chloroacetic acid→2-(2-azidoethoxy)acetic acid→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Hydroxypropionitrile→2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid→(2S)-2-methoxy-2-phenylethan-1-ol→3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-azidoethan-1-ol→2-Chloroacetic acid→2-(2-azidoethoxy)acetic acid→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Hydroxypropionitrile→2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid→(2S)-2-methoxy-2-phenylethan-1-ol→3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
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