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CAS 1032564-18-3
((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine
Codes: VILD-014
Application context (from source-drug indications)
Type 2 diabetesVildagliptinSchizophreniaVildagliptinDyslipidaemiaVildagliptinInsulin resistanceVildagliptinType 1 diabetesVildagliptinDiabetesVildagliptin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vildagliptin | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→tert-butyl ((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycinate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride
(S)-pyrrolidine-2-carboxamide→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride→tert-butyl ((3s,5s,7s)-adamantan-1-yl)glycinate→((3s,5s,7s)-adamantan-1-yl)glycine→tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate
(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→2-oxoacetic acid→(E)-2-(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)imino)acetic acid
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