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CAS 1032757-58-6
(S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
Codes: APITO-007
Application context (from source-drug indications)
Prostate cancerApitolisibBreast cancerApitolisibSolid tumourApitolisibRenal cell carcinomaApitolisibNon-Hodgkin lymphomaApitolisibEndometrial cancerApitolisib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apitolisib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 3-amino-4-methylthiophene-2-carboxylate→7-methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichloro-7-methylthieno[3,2-d]pyrimidine→4-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→(S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one oxalate→(S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one→(2-aminopyrimidin-5-yl)boronic acid→ethyl (S)-2-hydroxypropanoate→(S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one→5-bromopyrimidin-2-amine→APITO-012
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