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CAS 1034617-39-4
ethyl 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate
Codes: NMS-1286937-006
Application context (from source-drug indications)
Pancreatic cancerOnvansertibRenal cell carcinomaOnvansertibBreast cancerOnvansertib三阴性乳腺癌Onvansertib炎性乳腺癌OnvansertibMetastatic breast cancerOnvansertib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Onvansertib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
NMS-1286937→5-bromo-2-(trifluoromethoxy)aniline→1-methylpiperazine→5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)aniline→1-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)guanidine→(Z)-ethyl 6-((dimethylamino)methylene)-1-(2-hydroxyethyl)-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→ethyl 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→potassium 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→ammonium 1H-benzo[d][1,2,3]triazole-1-carboxylate→ethyl 2-(3-ethoxy-2-oxocyclohex-3-en-1-yl)-2-oxoacetate→ethyl 1-(2-hydroxyethyl)-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
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