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CAS 105-45-3
methyl 3-oxobutanoate1-Methoxybutane-1,3-dioneMethyl acetoacetate
Codes: PALB-052, (IV)1024528-3-a, (II)638294-10-a,(II)638294-10-b, Amoxicillin-019, FIMA-009, Lercanidipine Hydrochloride-008, (IV)70425-1-a
Application context (from source-drug indications)
Breast cancerPalbociclibNon-small cell lung cancerPralsetinibThyroid cancerPralsetinibMedullary thyroid cancerPralsetinibSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneHelicobacter pylori infectionAmoxicillin/Omeprazole/RifabutinDyspepsiaAmoxicillin/Omeprazole/RifabutinEssential hypertensionAmlodipine Besylate/Fimasartan PotassiumHypertensionAmlodipine Besylate/Fimasartan PotassiumDuodenal ulcerRabeprazole Sodium/Metronidazole/AmoxicillinImmune thrombocytopenic purpuraRabeprazole Sodium/Metronidazole/AmoxicillinGastric ulcerRabeprazole Sodium/Metronidazole/AmoxicillinGastritisRabeprazole Sodium/Metronidazole/AmoxicillinHelicobacter pylori infectionRabeprazole Sodium/Metronidazole/AmoxicillinMarginal zone B-cell lymphomaClarithromycin/Rabeprazole Sodium/AmoxicillinDuodenal ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinImmune thrombocytopenic purpuraClarithromycin/Rabeprazole Sodium/AmoxicillinGastric ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinGastritisClarithromycin/Rabeprazole Sodium/AmoxicillinHelicobacter pylori infectionClarithromycin/Rabeprazole Sodium/AmoxicillinEssential hypertensionValsartan/Lercanidipine HydrochlorideBacterial infectionAmoxicillin SodiumHypertensionFimasartan Potassium TrihydrateEssential hypertensionFimasartan Potassium TrihydrateHypercholesterolaemiaFimasartan Potassium TrihydrateChronic renal impairmentFimasartan Potassium TrihydrateRenal impairmentFimasartan Potassium TrihydrateHepatic function declineFimasartan Potassium TrihydrateHypertensionLercanidipine HydrochlorideBacterial infectionFloxacillin sodium蜂窝织炎Floxacillin sodiumChronic renal impairmentFloxacillin sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Palbociclib | Tier A — Act now | 2027 |
| Pralsetinib | Tier C — Watch / trade | 2031 |
| Finerenone | Tier C — Watch / trade | 2030 |
| Amoxicillin/Omeprazole/Rifabutin | Tier C — Watch / trade | - |
| Amlodipine Besylate/Fimasartan Potassium | Tier C — Watch / trade | - |
| Rabeprazole Sodium/Metronidazole/Amoxicillin | Tier C — Watch / trade | - |
| Clarithromycin/Rabeprazole Sodium/Amoxicillin | Tier C — Watch / trade | - |
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Amoxicillin Sodium | Tier C — Watch / trade | - |
| Fimasartan Potassium Trihydrate | Tier C — Watch / trade | - |
| Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Floxacillin sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→5-bromo-2-nitropyridine→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate→piperazine→1-(6-nitropyridin-3-yl)piperazine→PALB-044→(Z)-tert-butyl 4-(6-(2,3-bis(tert-butoxycarbonyl)guanidino)pyridin-3-yl)piperazine-1-carboxylate→1-(5-(piperazin-1-yl)pyridin-2-yl)guanidine hydrochloride→(E)-methyl 2-acetylbut-2-enoate→6-acetyl-4-amino-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→6-acetyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→chlorocyclopentane→6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one→methyl 3-oxobutanoate
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→Methyl 4-[imino(methoxy)methyl]-1-methoxycyclohexane-1-carboxylate hydrogen chloride→Methyl trans-4-carbamimidoyl-1-methoxycyclohexane-1-carboxylate→1-Methoxybutane-1,3-dione→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→Methyl trans-4-[4-[(methanesulfonyl)oxy]-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→3-Amino-5-methylpyrazole→Methyl (1s,4s)-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate→(1s,4s)-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylic acid→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride
4-Bromo-2-methoxybenzaldehyde→1-Methoxybutane-1,3-dione→Methyl (2Z)-2-[(4-bromo-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→Methyl 4-(4-bromo-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→Methyl 4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Methyl (4S)-4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid
1-Methoxybutane-1,3-dione→4-Amino-5-methylpyridin-2(1H)-one→(Diethoxymethoxy)ethane→Methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→3-Fluoro-4-formylbenzonitrile→Methyl 2-[(4-cyano-2-fluorophenyl)methylidene]-3-oxobutanoate→Methyl 4-(4-cyano-2-fluorophenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Methyl 4-(4-cyano-2-fluorophenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Methyl (4S)-4-(4-cyano-2-fluorophenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Natrium methoxide
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole→2-(2-butyl-4-methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,6-dihydropyrimidin-5-yl)-N,N-dimethylacetamide→methyl 3-oxobutanoate→2-chloro-N,N-dimethylacetamide→methyl 2-acetyl-4-(dimethylamino)-4-oxobutanoate→ pentanimidamide;hydrochloride→methyl 2-acetyl-4-(dimethylamino)-4-oxobutanoate
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
1-Methoxybutane-1,3-dione→1-Chloro-2-methyl-2-propanol→1-Chloro-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-Chloro-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→3-(1-Chloro-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→3-(1-Bromo-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→1-Bromo-2-methylpropan-2-ol→(3,3-Diphenylpropyl)(methyl)amine
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester
(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-Methyl 3-aminobut-2-enoate→Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol
1-Methoxybutane-1,3-dione→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Methyl acetoacetate→3-Hydroxypropionitrile→2-Cyanoethyl 3-oxobutanoate→(E)-2-cyanoethyl 3-aminobut-2-enoate→3-Nitrobenzaldehyde→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(2-Cyanoethyl) 5-Methyl E
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole→2-(2-butyl-4-methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,6-dihydropyrimidin-5-yl)-N,N-dimethylacetamide→methyl 3-oxobutanoate→2-chloro-N,N-dimethylacetamide→methyl 2-acetyl-4-(dimethylamino)-4-oxobutanoate→ pentanimidamide;hydrochloride→methyl 2-acetyl-4-(dimethylamino)-4-oxobutanoate
1-Methoxybutane-1,3-dione→1-Chloro-2-methyl-2-propanol→1-Chloro-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-Chloro-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→3-(1-Chloro-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→3-(1-Bromo-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→1-Bromo-2-methylpropan-2-ol→(3,3-Diphenylpropyl)(methyl)amine
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester
(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-Methyl 3-aminobut-2-enoate→Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol
1-Methoxybutane-1,3-dione→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Methyl acetoacetate→3-Hydroxypropionitrile→2-Cyanoethyl 3-oxobutanoate→(E)-2-cyanoethyl 3-aminobut-2-enoate→3-Nitrobenzaldehyde→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(2-Cyanoethyl) 5-Methyl E
2-Chloro-6-fluorobenzaldehyde→2-Chloro-6-fluorobenzaldehyde oxime→2-Chloro-6-fluoro-N-hydroxybenzenecarboximidoyl chloride→1-Methoxybutane-1,3-dione→Methyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate→3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid→3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride→(+)-6-Aminopenicillanic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | PD 0332991 HCl Pharmaceutical Intermediates | On request | On request | On request | — |
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