diethyl carbonate (105-58-8) intermediate

Application context (from source-drug indications)

OsteoporosisIbandronate Sodium Hydrate/ColecalciferolHypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumarateOsteoporosisIbandronate Sodium HydratePostmenopausal osteoporosisIbandronate Sodium HydrateHypercalcaemiaIbandronate Sodium HydrateBone injuryIbandronate Sodium HydrateBreast cancerIbandronate Sodium HydrateMetastatic cancerIbandronate Sodium HydrateHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol Fumarate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ibandronate Sodium Hydrate/Colecalciferol	Tier C — Watch / trade	-
Amlodipine Besylate/Bisoprolol Fumarate	Tier C — Watch / trade	-
Ibandronate Sodium Hydrate	Tier C — Watch / trade	-
Bisoprolol Fumarate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ibandronate Sodium Hydrate/ColecalciferolOptimised routesteps: 4total yield: 315.60 g

3-(methyl(pentyl)amino)propanoic acid hydrochloride→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-[methyl(pentyl)amino]propanoic acid;hydrochloride →diethyl carbonate

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 6total yield: /

Phenol→2-(Chloromethyl)oxirane→2-(phenoxymethyl)oxirane→N-Isopropylamine→Ethylene glycol monoisopropyl ether→(2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine→Diethyl carbonate→5-(phenoxymethyl)-3-(propan-2-yl)-1,3-oxazolidin-2-one→5-[4-(chloromethyl)phenoxymethyl]-3-(propan-2-yl)-1,3-oxazolidin-2-one→3-(propan-2-yl)-5-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)-1,3-oxazolidin-2-one

Ibandronate Sodium HydrateOptimised routesteps: 4total yield: 315.60 g

3-(methyl(pentyl)amino)propanoic acid hydrochloride→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-[methyl(pentyl)amino]propanoic acid;hydrochloride →diethyl carbonate

Bisoprolol FumarateOptimised routesteps: 6total yield: /

Phenol→2-(Chloromethyl)oxirane→2-(phenoxymethyl)oxirane→N-Isopropylamine→Ethylene glycol monoisopropyl ether→(2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine→Diethyl carbonate→5-(phenoxymethyl)-3-(propan-2-yl)-1,3-oxazolidin-2-one→5-[4-(chloromethyl)phenoxymethyl]-3-(propan-2-yl)-1,3-oxazolidin-2-one→3-(propan-2-yl)-5-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)-1,3-oxazolidin-2-one

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.