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CAS 1058156-60-7
1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylic acid
Codes: ANLO-012
Application context (from source-drug indications)
Alveolar soft part sarcomaAnlotinib DihydrochlorideHepatocellular carcinomaAnlotinib DihydrochlorideEndometrial cancerAnlotinib DihydrochlorideThyroid cancerAnlotinib DihydrochlorideMedullary thyroid cancerAnlotinib DihydrochlorideSmall cell lung cancerAnlotinib Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Anlotinib Dihydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
dimethyl cyclopropane-1,1-dicarboxylate→1-(methoxycarbonyl)cyclopropane-1-carboxylic acid→methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate→1-(4-hydroxy-3-methoxyphenyl)ethan-1-one→methyl 1-((4-acetyl-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-2-methoxy-5-nitrophenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-5-amino-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-hydroxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→4-fluoro-2-methyl-1H-indol-5-ol→methyl 1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylic acid→benzyl (1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamate
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