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CAS 105876-27-5
3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester
Codes: Atorvastatin-059
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 4total yield: 41.5g(Atorvastatin-047)
4-Cyano-3(R)-hydroxybutyric acid methyl ester→3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester→(3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-4-cyanobutanoic acid→3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentanenitrile→5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol
4-Cyano-3(R)-hydroxybutyric acid methyl ester→3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester→(3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-4-cyanobutanoic acid→3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentanenitrile→5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol
Intermediates available on this site
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