CAS 106-37-6

1,4-dibromobenzene1,4-Dibromobenzene

Codes: IRBE-010, ANID-015, Ketoconazole-024, Ioflupane (123I)-012

Application context (from source-drug indications)

HypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypertensionIrbesartan/TrichlormethiazideCandidiasisAnidulafunginCandidaemiaAnidulafunginFungal infectionAnidulafunginPeritonitisAnidulafunginAbscessAnidulafunginRespiratory tract infectionAnidulafunginFungal infectionNaftifine hydrochloride/KetoconazoleOesophageal diseaseIrbesartanHypertensionIrbesartanDiabetic nephropathyIrbesartanHypercholesterolaemiaIrbesartanAlbuminuriaIrbesartanType 2 diabetesIrbesartanCushing's syndromeKetoconazole头皮屑KetoconazolePityriasis versicolorKetoconazole皮肤念珠菌病KetoconazoleTineaKetoconazole脂溢性皮炎KetoconazoleLewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Atorvastatin Calcium Hydrate/Irbesartan	Tier C — Watch / trade	-
Irbesartan/Trichlormethiazide	Tier C — Watch / trade	-
Anidulafungin	Tier C — Watch / trade	-
Naftifine hydrochloride/Ketoconazole	Tier C — Watch / trade	-
Irbesartan	Tier B — Position early	-
Ketoconazole	Tier C — Watch / trade	-
Ioflupane (123I)	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin Calcium Hydrate/IrbesartanOptimised routesteps: 5total yield: 380.00 mg

1,4-dibromobenzene→4-bromobenzaldehyde→(4-bromophenyl)methanol→1-bromo-4-(bromomethyl)benzene→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride→3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid

Irbesartan/TrichlormethiazideOptimised routesteps: 5total yield: 380.00 mg

AnidulafunginOptimised routesteps: 5total yield: 14.6g (ANID-008)

1,4-Dibromobenzene→1,4-Phenylenediboronic acidd→4-Bromophenyl pentyl ether→Ethyl 4-iodobenzoate→4-Bromobenzoic acid ethyl ester→Ethyl 4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxylate→4-Ethoxycarbonylphenylmagnesium bromide→4-Bromophenyl tosylate→Ethyl 4'-[(4-methylbenzene-1-sulfonyl)oxy][1,1'-biphenyl]-4-carboxylate→4-Pentoxyphenylmagnesium bromide→4''-(Pentyloxy)-p-terphenyl-4-carboxylic acid

Naftifine hydrochloride/KetoconazoleOptimised routesteps: 1total yield: /

1,4-Dibromobenzene→(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol→4-[(4-Bromophenoxy)methyl]-2,2-dimethyl-1,3-dioxolane

IrbesartanOptimised routesteps: 5total yield: 380.00 mg

KetoconazoleOptimised routesteps: 1total yield: /

1,4-Dibromobenzene→(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol→4-[(4-Bromophenoxy)methyl]-2,2-dimethyl-1,3-dioxolane

Ioflupane (123I)Optimised routesteps: 8total yield: /

8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	4-(4'-Pentoxy-4-biphenylyl)benzoic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	1-(Diphenylmethyl)-3-hydroxyazetidine Pharmaceutical Intermediates	On request	On request	On request	—

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