CAS 106-94-5

1-bromopropane

Codes: TICA-044, SOLIF-017, ROTI-037

Application context (from source-drug indications)

StrokeTicagrelorAcute coronary syndromeTicagrelorMyocardial infarctionTicagrelorPeripheral vascular diseaseTicagrelorLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideRestless legs syndromeRotigotineParkinson's diseaseRotigotineSubstance-related disorderRotigotineDrug-related adverse effects and reactionsRotigotineTissue adhesionsRotigotinePostoperative painRotigotineOveractive bladderSolifenacin SuccinateUrge incontinenceSolifenacin SuccinateUrinary tract diseaseSolifenacin Succinate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ticagrelor	Tier B — Position early	2029
Solifenacin Succinate/Tamsulosin Hydrochloride	Tier C — Watch / trade	-
Rotigotine	Tier C — Watch / trade	-
Solifenacin Succinate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

TicagrelorOptimised routesteps: 5total yield: 192 mg

4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride

Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 2total yield: 1.1 g

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→1-bromopropane→propyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

RotigotineOptimised routesteps: 4total yield: 79.8 g

5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine→1-bromopropane→2-(2-bromoethyl)thiophene→(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine

Solifenacin SuccinateOptimised routesteps: 2total yield: 1.1 g

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→1-bromopropane→propyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	5-Methoxy-2-tetralone Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	(S)-2-AMINO-5-METHOXYTETRALIN HYDROCHLORIDE Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	(S)-2-Amino-5-methoxytetralin Hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	(S)-2-Amino-5-methoxytetralin (S)-mandelate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopenta[d][1,3]dioxol -4-yloxy)ethanol L-tataric acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)hydroxy(phenyl)ethanoate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.