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CAS 106-96-7
2-Propynyl bromide3-bromoprop-1-yne
Codes: (II)101438-54-a, PRAL-002
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylatePeripheral T-cell lymphomaPralatrexateT-cell lymphomaPralatrexateSolid tumourPralatrexateHaematological malignancyPralatrexateB-cell lymphomaPralatrexateCutaneous T-cell lymphomaPralatrexatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Pralatrexate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Methylpropionic acid ethyl ester→2-Propynyl bromide→Ethyl 2,2-dimethylpent-4-ynoate→2,2-Dimethylpent-4-ynoic acid→1-Chloro-3-methyl-2-butene→2,2-Dimethylpent-3-ynoic acid→N-Methoxy-N-methylamine hydrochloride→N-Methoxy-N,2,2-trimethylpent-3-ynamide→chloro(3-methylbut-2-en-1-yl)magnesium→2,6,6-Trimethylnon-2-en-7-yn-5-one→Cyanotrimethylsilane→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enenitrile→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enal→(2E)-1-[1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)trisilan-2-yl]-2-[(2S)-2-methyl-2-[3-(trityloxy)propyl]cyclohexylidene]hydrazine→(3aS,7Z,9aS,13bS)-6,9a,14,14-Tetramethyl-9,9a,10,11,12,13b-hexahydro-4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,2S)-5-Methyl-2-(2-methylpent-3-yn-2-yl)-1-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]hex-4-ene-1,2-diol→(4S,5S)-4-(3-Methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-5-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]-1,3-dioxolan-2-one→(4S,5S)-5-[(6S)-6-(3-Hydroxypropyl)-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S)-5-[(6S)-6-Allyl-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→(S)-diethyl 2-aminopentanedioate hydrochloride→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate hydrobromide→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→sodium 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate→(S)-diethyl 2-aminopentanedioate
2-Methylpropionic acid ethyl ester→2-Propynyl bromide→Ethyl 2,2-dimethylpent-4-ynoate→2,2-Dimethylpent-4-ynoic acid→1-Chloro-3-methyl-2-butene→2,2-Dimethylpent-3-ynoic acid→N-Methoxy-N-methylamine hydrochloride→N-Methoxy-N,2,2-trimethylpent-3-ynamide→chloro(3-methylbut-2-en-1-yl)magnesium→2,6,6-Trimethylnon-2-en-7-yn-5-one→Cyanotrimethylsilane→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enenitrile→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enal→(2E)-1-[1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)trisilan-2-yl]-2-[(2S)-2-methyl-2-[3-(trityloxy)propyl]cyclohexylidene]hydrazine→(3aS,7Z,9aS,13bS)-6,9a,14,14-Tetramethyl-9,9a,10,11,12,13b-hexahydro-4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,2S)-5-Methyl-2-(2-methylpent-3-yn-2-yl)-1-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]hex-4-ene-1,2-diol→(4S,5S)-4-(3-Methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-5-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]-1,3-dioxolan-2-one→(4S,5S)-5-[(6S)-6-(3-Hydroxypropyl)-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S)-5-[(6S)-6-Allyl-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one
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