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CAS 106192-66-9

(2R,3R,4S,5R)-2-azido-6-methylenetetrahydro-2H-pyran-3,4,5-triyl triacetate

Codes: MIGA-022

Application context (from source-drug indications)

Fabry diseaseMigalastat Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Migalastat HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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Migalastat HydrochlorideOptimised routesteps: 4total yield: 10.5 mg
(2R,3R,4S,5R)-2-azido-6-methylenetetrahydro-2H-pyran-3,4,5-triyl triacetate→(3R,4R,5R,6R)-2-(acetoxymethyl)-6-azido-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate→(3R,4R,5R,6R)-6-azido-2-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2R,3R,4S,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol

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