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CAS 106454-67-5

4(S)-Hydroxy-4-(4-hydroxyphenyl)-L-threonine

Codes: ANID-045, (XXXII)796686-1-e

Application context (from source-drug indications)

CandidiasisAnidulafunginCandidaemiaAnidulafunginFungal infectionAnidulafunginPeritonitisAnidulafunginAbscessAnidulafunginRespiratory tract infectionAnidulafungin侵袭性念珠菌病Rezafungin acetateCandidiasisRezafungin acetateCandidaemiaRezafungin acetate卡氏肺囊虫感染Rezafungin acetate侵袭性真菌感染Rezafungin acetateAspergillus infectionRezafungin acetate

Source drugs (routes using this intermediate)

DrugTierExpiry
AnidulafunginTier C — Watch / trade-
Rezafungin acetateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

AnidulafunginOptimised routesteps: 4total yield: 27.9g (ANID-033)
(2S,3E)-2-[[(Benzyloxy)carbonyl]amino]-4-[4-(benzyloxy)phenyl]but-3-enoic acid→(4S)-N-[(Benzyloxy)carbonyl]-4-[4-(benzyloxy)phenyl]-4-hydroxy-L-threonine→4(S)-Hydroxy-4-(4-hydroxyphenyl)-L-threonine→(4S)-N-[[(9H-Fluoren-9-yl)oxy]carbonyl]-4-hydroxy-4-(4-hydroxyphenyl)-L-threonine→(4S)-O-Acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonine
Rezafungin acetateOptimised routesteps: 4total yield: /
(4S)-O-Acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonine→(2S,3E)-2-[[(Benzyloxy)carbonyl]amino]-4-[4-(benzyloxy)phenyl]but-3-enoic acid→(4S)-N-[(Benzyloxy)carbonyl]-4-[4-(benzyloxy)phenyl]-4-hydroxy-L-threonine→4(S)-Hydroxy-4-(4-hydroxyphenyl)-L-threonine→(4S)-N-[[(9H-Fluoren-9-yl)oxy]carbonyl]-4-hydroxy-4-(4-hydroxyphenyl)-L-threonine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Qualified Partner — East China API Works4-(4'-Pentoxy-4-biphenylyl)benzoic acid
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site1-(Diphenylmethyl)-3-hydroxyazetidine
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.