CAS 1066-51-9

(aminomethyl)phosphonic acid

Codes: TELA-007

Application context (from source-drug indications)

Ventilator-associated pneumoniaTelavancin HydrochlorideBacterial pneumoniaTelavancin HydrochlorideHospital-acquired pneumoniaTelavancin HydrochlorideHealthcare-associated pneumoniaTelavancin HydrochlorideComplicated skin and skin structure infectionTelavancin HydrochlorideStaphylococcal infectionTelavancin Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Telavancin Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Telavancin HydrochlorideOriginator routesteps: 5total yield: 3.05 g

2-(decylamino)ethan-1-ol→(9H-fluoren-9-yl)methyl decyl(2-hydroxyethyl)carbamate→(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-→Vancomycin, N3''-[2-(decylamino)ethyl]-→(aminomethyl)phosphonic acid

Telavancin HydrochlorideOptimised routesteps: 3total yield: /

(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→(aminomethyl)phosphonic acid→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-29-[[(phosphonomethyl)amino]methyl]-

Telavancin HydrochlorideOptimised routesteps: 4total yield: /

(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-→(aminomethyl)phosphonic acid→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-29-[[(phosphonomethyl)amino]methyl]-

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