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CAS 107-22-2
EthanedialGlyoxal
Codes: Tazobactam Sodium-013, Metronidazole hydrochloride-001
Application context (from source-drug indications)
Intra-abdominal infectionTazobactam Sodium/CeftolozaneVentilator-associated pneumoniaTazobactam Sodium/CeftolozaneUrinary tract infectionTazobactam Sodium/CeftolozaneCommunity-acquired bacterial pneumoniaTazobactam Sodium/CeftolozanePyelonephritisTazobactam Sodium/CeftolozaneHospital-acquired pneumoniaTazobactam Sodium/CeftolozaneDuodenal ulcerRabeprazole Sodium/Metronidazole/AmoxicillinImmune thrombocytopenic purpuraRabeprazole Sodium/Metronidazole/AmoxicillinGastric ulcerRabeprazole Sodium/Metronidazole/AmoxicillinGastritisRabeprazole Sodium/Metronidazole/AmoxicillinHelicobacter pylori infectionRabeprazole Sodium/Metronidazole/AmoxicillinBacterial infectionCeftazidime/Tazobactam SodiumRespiratory tract infectionCeftazidime/Tazobactam SodiumUrinary tract infectionCeftazidime/Tazobactam SodiumTrichomoniasisMiconazole/Metronidazole/LidocaineCandidiasisMiconazole/Metronidazole/LidocaineVaginitisMiconazole/Metronidazole/LidocaineBacterial infectionTazobactam SodiumBacterial infectionMetronidazole hydrochlorideIntra-abdominal infectionMetronidazole hydrochlorideBacteraemiaMetronidazole hydrochlorideSkin and skin structure infectionMetronidazole hydrochlorideLower respiratory tract infectionMetronidazole hydrochlorideEndocarditisMetronidazole hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tazobactam Sodium/Ceftolozane | Tier C — Watch / trade | - |
| Rabeprazole Sodium/Metronidazole/Amoxicillin | Tier C — Watch / trade | - |
| Ceftazidime/Tazobactam Sodium | Tier C — Watch / trade | - |
| Miconazole/Metronidazole/Lidocaine | Tier C — Watch / trade | - |
| Tazobactam Sodium | Tier C — Watch / trade | - |
| Metronidazole hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester→Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide→Ethanedial→Diamine→1,1'-(Ethane-1,2-diylidene)dihydrazine→1H-1,2,3-Triazol-1-amine→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→2-Propynoic acid→(2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester
Rabeprazole Sodium/Metronidazole/AmoxicillinOptimised routesteps: 6total yield: 8.5g(Metronidazole (Free))
Glyoxal→Ethanal→2-Methylglyoxaline→2-Methyl-4(5)-nitroimidazole→Ethylene chlorohydrin→Ethyl nitrile→Methyl ethanimidoate hydrochloride→2,2-Dimethoxyethanamine→N-(2,2-Dimethoxyethyl)ethanimidamide
(2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester→Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide→Ethanedial→Diamine→1,1'-(Ethane-1,2-diylidene)dihydrazine→1H-1,2,3-Triazol-1-amine→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→2-Propynoic acid→(2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester
Glyoxal→Ethanal→2-Methylglyoxaline→2-Methyl-4(5)-nitroimidazole→Ethylene chlorohydrin→Ethyl nitrile→Methyl ethanimidoate hydrochloride→2,2-Dimethoxyethanamine→N-(2,2-Dimethoxyethyl)ethanimidamide
(2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester→Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide→Ethanedial→Diamine→1,1'-(Ethane-1,2-diylidene)dihydrazine→1H-1,2,3-Triazol-1-amine→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→2-Propynoic acid→(2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester
Glyoxal→Ethanal→2-Methylglyoxaline→2-Methyl-4(5)-nitroimidazole→Ethylene chlorohydrin→Ethyl nitrile→Methyl ethanimidoate hydrochloride→2,2-Dimethoxyethanamine→N-(2,2-Dimethoxyethyl)ethanimidamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.