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CAS 107-30-2
1-Chloro-1-methoxymethanechloro(methoxy)methane
Codes: Xylometazoline Hydrochloride-004, CRISA-003, Oxymetazoline Hydrochloride-002
Application context (from source-drug indications)
Atopic dermatitisCrisaboroleDermatitisCrisaboroleEczemaCrisaboroleAlopecia areataCrisaboroleLocalised sclerodermaCrisaborolePlaque psoriasisCrisaboroleAnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideNasal congestionXylometazoline HydrochlorideRhinitisXylometazoline HydrochlorideCommon coldXylometazoline HydrochlorideNasal congestionOxymetazoline HydrochlorideCongestionOxymetazoline HydrochloridePtosisOxymetazoline HydrochlorideFunctional faecal incontinenceOxymetazoline HydrochlorideRosaceaOxymetazoline HydrochlorideRashOxymetazoline Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dexpanthenol/Xylometazoline Hydrochloride | Tier C — Watch / trade | - |
| Crisaborole | Tier C — Watch / trade | - |
| Oxymetazoline Hydrochloride/Tetracaine Hydrochloride | Tier C — Watch / trade | - |
| Xylometazoline Hydrochloride | Tier C — Watch / trade | - |
| Oxymetazoline Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dexpanthenol/Xylometazoline HydrochlorideOptimised routesteps: 5total yield: 12.4g(Xylometazoline Hydrochloride (API))
1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate
Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 5total yield: 7.5g(Oxymetazoline hydrochloride (API))
4-tert-Butyl-2,6-dimethylbenzene-1,3-diol→1-Chloro-1-methoxymethane→6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→4,5-Dihydro-1H-imidazole-2-thiol→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→Ethane-1,2-diamine 4-methylbenzenesulfonate→Ethane-1,2-diamine hydrobromide
Xylometazoline HydrochlorideOptimised routesteps: 5total yield: 12.4g(Xylometazoline Hydrochloride (API))
1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate
Oxymetazoline HydrochlorideOptimised routesteps: 5total yield: 7.5g(Oxymetazoline hydrochloride (API))
4-tert-Butyl-2,6-dimethylbenzene-1,3-diol→1-Chloro-1-methoxymethane→6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→4,5-Dihydro-1H-imidazole-2-thiol→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→Ethane-1,2-diamine 4-methylbenzenesulfonate→Ethane-1,2-diamine hydrobromide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2-BROMO-5-HYDROXYBENZALDEHYDE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-[4-bromo-3-(hydroxymethyl)phenoxy]benzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | [2-bromo-5-(4-cyanophenoxy)phenyl]methyl acetate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.