CAS 108-86-1

bromobenzeneBromanylbenzene

Codes: GLYC-018, (VI)70353-2-a

Application context (from source-drug indications)

AsthmaBudesonide/Formoterol fumarate/Glycopyrronium BromideChronic obstructive pulmonary diseaseBudesonide/Formoterol fumarate/Glycopyrronium BromideBacterial and fungal infectionBetamethasone/Clotrimazole/Gentamicin SulfateChronic obstructive pulmonary diseaseIndacaterol Maleate/Glycopyrronium BromideSialorrhoeaGlycopyrronium BromideChronic obstructive pulmonary diseaseGlycopyrronium BromideDuodenal ulcerGlycopyrronium BromideGastric ulcerGlycopyrronium BromideGastritisGlycopyrronium BromideAnaesthesiaGlycopyrronium BromideCandidiasisClotrimazoleVulvovaginal candidiasisClotrimazoleAspergillus infectionClotrimazoleOtitis externaClotrimazolePruritusClotrimazolePityriasis versicolorClotrimazole

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Budesonide/Formoterol fumarate/Glycopyrronium Bromide	Tier B — Position early	-
Betamethasone/Clotrimazole/Gentamicin Sulfate	Tier C — Watch / trade	-
Indacaterol Maleate/Glycopyrronium Bromide	Tier B — Position early	-
Glycopyrronium Bromide	Tier C — Watch / trade	-
Clotrimazole	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Budesonide/Formoterol fumarate/Glycopyrronium BromideOptimised routesteps: 3total yield: /

1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-oxoacetic acid→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate→bromobenzene

Betamethasone/Clotrimazole/Gentamicin SulfateOptimised routesteps: 6total yield: /

(2-Chlorophenyl)(iodo)magnesium→(14C)-2-Chlorobenzoic acid→(14C)-2-Chlorobenzoyl chloride→Benzene→(14C)-2-Chlorobenzophenone→Bromanylbenzene→(14C)-(2-Chlorophenyl)diphenylmethanol→(14C)-1-(2-Chlorophenyl)-1,1-diphenylmethyl chloride→1,3-Diaza-2,4-cyclopentadiene→(14C)-1-[1-(2-Chlorophenyl)-1,1-diphenylmethyl]-1H-imidazole

Indacaterol Maleate/Glycopyrronium BromideOptimised routesteps: 3total yield: /

1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-oxoacetic acid→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate→bromobenzene

Glycopyrronium BromideOptimised routesteps: 3total yield: /

1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-oxoacetic acid→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate→bromobenzene

ClotrimazoleOptimised routesteps: 6total yield: /

Intermediates available on this site

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