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CAS 1089192-64-2

((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine

Codes: ROMI-033

Application context (from source-drug indications)

Peripheral T-cell lymphomaRomidepsinLymphomaRomidepsinPhaeochromocytomaRomidepsinCutaneous T-cell lymphomaRomidepsinNon-Hodgkin lymphomaRomidepsinMelanomaRomidepsin

Source drugs (routes using this intermediate)

DrugTierExpiry
RomidepsinTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

RomidepsinOptimised routesteps: 8total yield: 53.6 mg
(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid→ROMI-028→ROMI-029→ROMI-030→ROMI-031→ROMI-032→((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine→ROMI-034→ROMI-035→(S,E)-3-hydroxy-1-((R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-(tritylthio)hept-4-en-1-one

Intermediates available on this site

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