CAS 109-09-1

2-chloropyridine

Codes: PERAM-009, LASM-009

Application context (from source-drug indications)

Tonic-clonic seizurePerampanel HydratePartial-onset seizurePerampanel HydrateEpilepsyPerampanel HydrateSeizurePerampanel HydrateMigraineLasmiditan hemisuccinateDrug-related adverse effects and reactionsLasmiditan hemisuccinate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Perampanel Hydrate	Tier C — Watch / trade	2028
Lasmiditan hemisuccinate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Perampanel HydrateOriginator routesteps: 6total yield: /

5-bromopyridin-2-amine→5-bromo-3-iodopyridin-2-amine→5-bromo-3-iodopyridin-2(1H)-one→phenylboronic acid→5-bromo-3-iodo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2-(5-bromo-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→2-(2-oxo-1-phenyl-5-(tributylstannyl)-1,2-dihydropyridin-3-yl)benzonitrile→2-chloropyridine

Lasmiditan hemisuccinateOptimised routesteps: 5total yield: /

(6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone→2,4,6-trifluorobenzoyl chloride→2-chloropyridine→N-methoxy-N,1-dimethylpiperidine-4-carboxamide→(6-chloropyridin-2-yl)(1-methylpiperidin-4-yl)methanone→diphenylmethanimine→(6-((diphenylmethylene)amino)pyridin-2-yl)(1-methylpiperidin-4-yl)methanone

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