CAS 1098924-76-5

N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

Codes: SPAR-006

Application context (from source-drug indications)

局灶性节段性肾小球硬化症Sparsentan免疫球蛋白a肾病Sparsentan抗中性粒细胞胞浆抗体相关性血管炎SparsentanKidney diseaseSparsentanAlport 综合征Sparsentan过敏性紫癜Sparsentan

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Sparsentan	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

SparsentanOriginator routesteps: 7total yield: 26 g

ethyl 4-bromo-3-methylbenzoate→ethyl 4-bromo-3-(bromomethyl)benzoate→ethyl 4-bromo-3-(ethoxymethyl)benzoate→(2-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)phenyl)boronic acid→ethyl 2'-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)-2-(ethoxymethyl)-[1,1'-biphenyl]-4-carboxylate→N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide→4'-(bromomethyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide Pharmaceutical Intermediates	On request	On request	On request	—

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