← Back to patent-cliff list
CAS 110-00-9
1,4-Epoxy-1,3-butadienefuran
Codes: Atorvastatin-126, ROTI-028
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontiumRestless legs syndromeRotigotineParkinson's diseaseRotigotineSubstance-related disorderRotigotineDrug-related adverse effects and reactionsRotigotineTissue adhesionsRotigotinePostoperative painRotigotine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
| Rotigotine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 11total yield: 25g(Atorvastatin-017)
1,4-Epoxy-1,3-butadiene→(2E)-1,1,4,4-Tetramethoxybut-2-ene→2,2-Dimethoxyacetaldehyde→Nitrocarbol→tert-Butyl 4-bromo-3-oxobutanoate→1,1-Dimethoxy-3-nitropropan-2-ol→(1E)-3,3-Dimethoxy-1-nitroprop-1-ene→(2E)-3-Nitroprop-2-enal→Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc→tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate→4-Methylene-2-oxetanone→tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate→2-Propanone→tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester
1,4-Epoxy-1,3-butadiene→(2E)-1,1,4,4-Tetramethoxybut-2-ene→2,2-Dimethoxyacetaldehyde→Nitrocarbol→tert-Butyl 4-bromo-3-oxobutanoate→1,1-Dimethoxy-3-nitropropan-2-ol→(1E)-3,3-Dimethoxy-1-nitroprop-1-ene→(2E)-3-Nitroprop-2-enal→Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc→tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate→4-Methylene-2-oxetanone→tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate→2-Propanone→tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester
2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate→(S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol→1-chloro-3-methoxybenzene→furan→5-methoxy-1,4-dihydro-1,4-epoxynaphthalene→N-benzylpropan-1-amine→(1S,2S)-2-(benzyl(propyl)amino)-5-methoxy-1,2-dihydronaphthalen-1-ol→(1S,2S)-2-(benzyl(propyl)amino)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol→(1S,2S)-5-methoxy-2-(propylamino)-1,2,3,4-tetrahydronaphthalen-1-ol→tert-butyl ((1S,2S)-1-hydroxy-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)carbamate→(3aS,9bR)-6-methoxy-3-propyl-3a,4,5,9b-tetrahydronaphtho[2,1-d]oxazol-2(3H)-one→(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-Methoxy-2-tetralone Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (S)-2-AMINO-5-METHOXYTETRALIN HYDROCHLORIDE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (S)-2-Amino-5-methoxytetralin Hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (S)-2-Amino-5-methoxytetralin (S)-mandelate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.