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CAS 110-15-6
succinic acid
Codes: TREL-007, SOLIF-007, PRUC-021
Application context (from source-drug indications)
Type 2 diabetesTrelagliptin SuccinateDiabetesTrelagliptin SuccinateLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideConstipationPrucalopride SuccinatePostoperative complicationPrucalopride SuccinateEnteral feeding intolerancePrucalopride SuccinateOpioid-induced constipationPrucalopride SuccinatePainPrucalopride SuccinateIntestinal pseudo-obstructionPrucalopride SuccinateOveractive bladderSolifenacin SuccinateUrge incontinenceSolifenacin SuccinateUrinary tract diseaseSolifenacin Succinate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Trelagliptin Succinate | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Prucalopride Succinate | Tier C — Watch / trade | - |
| Solifenacin Succinate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-bromo-4-fluoro-2-methylbenzene→4-fluoro-2-methylbenzonitrile→2-(bromomethyl)-4-fluorobenzonitrile→6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→(R)-piperidin-3-amine→succinic acid→(R)-2,5-diaminopentanoic acid hydrochloride→(R)-methyl 2,5-diaminopentanoate→(R)-3-aminopiperidin-2-one hydrochloride→(R)-piperidin-3-amine
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→succinic acid→nicotinamide→1,4,5,6-tetrahydropyridine-3-carboxamide→(R)-piperidine-3-carboxamide 4-methylbenzenesulfonate→(R)-1-(3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-3-carboxamide
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→succinic acid→perfluorophenyl (2,3,4,5-tetrafluorophenyl) carbonate→(R)-perfluorophenyl quinuclidin-3-yl carbonate
4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine→4-amino-2-hydroxybenzoic acid→methyl 4-amino-2-hydroxybenzoate→methyl 4-acetamido-2-hydroxybenzoate→methyl 4-acetamido-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-2-(2-bromoethoxy)-5-chlorobenzoate→methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate→4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide→succinic acid→piperidin-4-one hydrochloride hydrate→1-bromo-3-methoxypropane→1-(3-methoxypropyl)piperidin-4-one
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→succinic acid→perfluorophenyl (2,3,4,5-tetrafluorophenyl) carbonate→(R)-perfluorophenyl quinuclidin-3-yl carbonate
Intermediates available on this site
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