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CAS 110-17-8

fumaric acidtrans-2-Butenedioic acid

Codes: LURA-007, VONO-011, Enalapril-006

Application context (from source-drug indications)

Major depressive disorderLurasidone HydrochlorideSchizophreniaLurasidone HydrochlorideManiaLurasidone HydrochlorideDepressive disorderLurasidone HydrochloridePeptic ulcer bleedingVonoprazan AcetateCardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHelicobacter pylori infectionVonoprazan FumarateOesophagitisVonoprazan FumarateGastro-oesophageal reflux diseaseVonoprazan FumarateHeartburnVonoprazan FumaratePeptic oesophagitisVonoprazan FumarateHelicobacter infectionVonoprazan FumarateEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril Maleate

Source drugs (routes using this intermediate)

DrugTierExpiry
Lurasidone HydrochlorideTier B — Position early2028
Vonoprazan AcetateTier C — Watch / trade2029
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilTier C — Watch / trade-
Vonoprazan FumarateTier C — Watch / trade-
Enalapril Maleate/Folic AcidTier C — Watch / trade-
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateTier C — Watch / trade-
Enalapril MaleateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Lurasidone HydrochlorideOptimised routesteps: 4total yield: /
fumaric acid→2,5-dihydrothiophene 1,1-dioxide→cyclohex-4-ene-1,2-dicarboxylic acid→cyclohexane-1,2-dicarboxylic acid→(R)-1-phenylethan-1-aminium (1R,2S)-2-carboxycyclohexane-1-carboxylate→(1R,2S)-cyclohexane-1,2-dicarboxylic acid
Vonoprazan AcetateOriginator routesteps: 10total yield: 912 mg (Vonoprazan Fumarate)
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
Vonoprazan AcetateOptimised routesteps: 5total yield: 20.7 g (Vonoprazan Fumarate)
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine→tert-butyl ((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate→pyridine-3-sulfonyl chloride→tert-butyl ((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate→fumaric acid
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 2total yield: 4.2g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(-)-L-Proline<-fgf->L-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→trans-2-Butenedioic acid
Vonoprazan FumarateOriginator routesteps: 10total yield: 912 mg
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
Vonoprazan FumarateOptimised routesteps: 5total yield: 20.7 g
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine→tert-butyl ((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate→pyridine-3-sulfonyl chloride→tert-butyl ((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate
Enalapril Maleate/Folic AcidOptimised routesteps: 2total yield: 4.2g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(-)-L-Proline<-fgf->L-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→trans-2-Butenedioic acid
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateOriginator routesteps: 10total yield: 912 mg (Vonoprazan Fumarate)
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateOptimised routesteps: 5total yield: 20.7 g (Vonoprazan Fumarate)
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine→tert-butyl ((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate→pyridine-3-sulfonyl chloride→tert-butyl ((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate→fumaric acid
Enalapril MaleateOptimised routesteps: 2total yield: 4.2g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(-)-L-Proline<-fgf->L-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→trans-2-Butenedioic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Taizhou GMP-like Site5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Workspyridine-3-sulfonyl chloride
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteVonoprazan
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site3-Pyridinesulfonyl chloride
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
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