Unibest
← Back to patent-cliff list

CAS 110-91-8

morpholineDiethylene oximide1-Oxa-4-azacyclohexane

Codes: APIX-012, CARF-022, PEMIGA-027, SOTA-004, COBI-025, Timolol Maleate-007, IXAB-012, (IV) 920279-1-a, (III) 920279-2-a, (II) 920279-3-a, LINE-002, CELE-008

Application context (from source-drug indications)

Pulmonary embolismApixabanVenous thrombosisApixabanPaget-Schroetter syndromeApixabanVenous thromboembolismApixabanThrombosisApixabanEmbolismApixabanMultiple myelomaCarfilzomibMyelomaPemigatinibLymphomaPemigatinibBile duct cancerPemigatinibCholangiocarcinomaPemigatinibBiliary tract cancerPemigatinibType 2 diabetesSotagliflozinChronic renal impairmentSotagliflozinHeart failureSotagliflozinHIV infectionCobicistatNon-small cell lung cancerCobicistatAcquired immunodeficiency syndromeCobicistatOcular hypertensionBrimonidine Tartrate/Timolol MaleateGlaucomaBrimonidine Tartrate/Timolol MaleateBreast cancerIxabepiloneMetastatic breast cancerIxabepiloneCervical cancerIxabepiloneProstate cancerIxabepiloneSolid tumourIxabepiloneNeutropeniaIxabepiloneOcular hypertensionBimatoprost/Timolol MaleateOpen-angle glaucomaBimatoprost/Timolol MaleateGlaucomaBimatoprost/Timolol MaleateOcular hypertensionTimolol MaleateGlaucomaTimolol MaleateOpen-angle glaucomaTimolol MaleateTrauma and injuryTimolol MaleateHypertensionTimolol MaleateMigraineTimolol MaleateNon-small cell lung cancerLazertinib MesylateHepatic function declineLazertinib Mesylate非复杂性皮肤和皮肤结构感染LinezolidPneumoniaLinezolidComplicated skin and skin structure infectionLinezolidBacteraemiaLinezolidBacterial infectionLinezolidHealthcare-associated pneumoniaLinezolidPainCelecoxibInflammatory diseaseCelecoxib关节周围炎Celecoxib肌腱炎Celecoxib颈肩腕综合征CelecoxibLow back painCelecoxib

Source drugs (routes using this intermediate)

DrugTierExpiry
ApixabanTier A — Act now2028
CarfilzomibTier B — Position early2029
PemigatinibTier C — Watch / trade2032
SotagliflozinTier C — Watch / trade2032
CobicistatTier C — Watch / trade-
Brimonidine Tartrate/Timolol MaleateTier C — Watch / trade-
IxabepiloneTier C — Watch / trade-
Bimatoprost/Timolol MaleateTier C — Watch / trade-
Timolol MaleateTier C — Watch / trade-
Lazertinib MesylateTier C — Watch / trade-
LinezolidTier B — Position early-
CelecoxibTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

IxabepiloneOriginator routesteps: 15total yield: /
N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N-methylpropionamide→5-bromopent-1-ene→(S)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethylhept-6-enamide→(1S,2S)-1-(((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)(methyl)amino)-2-methylhept-6-en-1-ol→(S)-2-methylhept-6-enal→3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-5-oxoheptanoic acid→(3S,6R,7S,8S)-3-((tert-butyldimethylsilyl)oxy)-7-hydroxy-4,4,6,8-tetramethyl-5-oxotridec-12-enoic acid→(S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-amine→(3S,6R,7S,8S)-3-((tert-butyldimethylsilyl)oxy)-7-hydroxy-4,4,6,8-tetramethyl-N-((S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-yl)-5-oxotridec-12-enamide→(4S,7R,8S,9S,16S,Z)-4-((tert-butyldimethylsilyl)oxy)-8-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)azacyclohexadec-13-ene-2,6-dione→(4S,7R,8S,9S,16S,Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)azacyclohexadec-13-ene-2,6-dione→morpholine→isobutyraldehyde→4-(2-methylprop-1-en-1-yl)morpholine→(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl pentanoate→2,2-dimethyl-3-oxopentanal→allylbis(4,6,6-trimethylbicyclo[3.1.1]hept-2-en-3-yl)borane→tert-butyldimethylsilyl trifluoromethanesulfonate→5-((tert-butyldimethylsilyl)oxy)-4,4-dimethyloct-7-en-3-one→3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-5-oxoheptanal→(S,E)-2-aminopent-3-enoic acid→(S,E)-2-((tert-butoxycarbonyl)amino)pent-3-enoic acid→tert-butyl (S,E)-(1-(methoxy(methyl)amino)-1-oxopent-3-en-2-yl)carbamate→tert-butyl (S,E)-(2-oxohept-5-en-3-yl)carbamate→((2-methylthiazol-4-yl)methyl)diphenylphosphine oxide→tert-butyl ((S,1E,5E)-2-methyl-1-(2-methylthiazol-4-yl)hepta-1,5-dien-3-yl)carbamate→methoxybis(4,6,6-trimethylbicyclo[3.1.1]hept-2-en-3-yl)borane

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Qualified Partner — East China API Works3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works3-Morpholino-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydropyridin.2(1H)-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteEthyl chloro[(4-methoxyphenyl)hydrazono]acetate
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site1-(4-Methoxyphenyl)-7-0xo-6-[4-(2-0xopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acidethyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteCarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site(alphaS)-alpha-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-L-phenylalanine methyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site3-phenyl-1H-pyrazole-4-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site4-Chloro-2-(methylsulfonyl)pyrimidine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API WorksN1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteL-xylose
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like SiteD-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.