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CAS 1118-89-4
(S)-diethyl 2-aminopentanedioate hydrochlorideDiethyl L-glutamate hydrochloride
Codes: PRAL-008, Folic Acid-031
Application context (from source-drug indications)
Peripheral T-cell lymphomaPralatrexateT-cell lymphomaPralatrexateSolid tumourPralatrexateHaematological malignancyPralatrexateB-cell lymphomaPralatrexateCutaneous T-cell lymphomaPralatrexateEssential hypertensionEnalapril Maleate/Folic AcidMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic Acid
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pralatrexate | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Folic Acid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→(S)-diethyl 2-aminopentanedioate hydrochloride→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene→2,3,5,6-Tetradeutero-4-nitrobenzoic acid→2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride→Diethyl L-glutamate hydrochloride→Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate→Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid
1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene→2,3,5,6-Tetradeutero-4-nitrobenzoic acid→2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride→Diethyl L-glutamate hydrochloride→Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate→Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid
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