← Back to patent-cliff list
CAS 112101-75-4
5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride
Codes: Tamsulosin Hydrochloride-005
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(R)-(-)-1-Phenylethylamine→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→1-(2-Bromoethoxy)-2-ethoxybenzene→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→2-(2-Ethoxyphenoxy)ethyl mesylate
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 9total yield: 50.8g(Tamsulosin (Free))
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 5total yield: 46.28gTamsulosin Hydrochloride (API)
2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(R)-(-)-1-Phenylethylamine→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→1-(2-Bromoethoxy)-2-ethoxybenzene→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→2-(2-Ethoxyphenoxy)ethyl mesylate
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
Dutasteride/Tamsulosin HydrochlorideOptimised routesteps: 5total yield: 46.28gTamsulosin Hydrochloride (API)
2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(R)-(-)-1-Phenylethylamine→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→1-(2-Bromoethoxy)-2-ethoxybenzene→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→2-(2-Ethoxyphenoxy)ethyl mesylate
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(R)-(-)-1-Phenylethylamine→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→1-(2-Bromoethoxy)-2-ethoxybenzene→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→2-(2-Ethoxyphenoxy)ethyl mesylate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.