CAS 1124-29-4

5-acetylpyridin-2(1H)-one

Codes: PERAM-024

Application context (from source-drug indications)

Tonic-clonic seizurePerampanel HydratePartial-onset seizurePerampanel HydrateEpilepsyPerampanel HydrateSeizurePerampanel Hydrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Perampanel Hydrate	Tier C — Watch / trade	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Perampanel HydrateOptimised routesteps: 5total yield: 62.8 g

5-acetyl-1-phenylpyridin-2(1H)-one→5-acetyl-3-bromo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborolan-2-yl)benzonitrile→2-(5-acetyl-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→(E)-3-(dimethylamino)acrylaldehyde→phenylboronic acid→1-(6-chloropyridin-3-yl)ethanone→5-acetylpyridin-2(1H)-one

Intermediates available on this site

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