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CAS 113020-21-6
1-(methoxycarbonyl)cyclopropane-1-carboxylic acid
Codes: DCC-2618-007, ANLO-002
Application context (from source-drug indications)
Gastrointestinal stromal tumourRipretinibAlveolar soft part sarcomaAnlotinib DihydrochlorideHepatocellular carcinomaAnlotinib DihydrochlorideEndometrial cancerAnlotinib DihydrochlorideThyroid cancerAnlotinib DihydrochlorideMedullary thyroid cancerAnlotinib DihydrochlorideSmall cell lung cancerAnlotinib Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ripretinib | Tier C — Watch / trade | 2032 |
| Anlotinib Dihydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide hydrochloride→2-chloropyridin-4-ol→1,2,4-trifluoro-5-nitrobenzene→2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine→4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline→1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline→1-(methoxycarbonyl)cyclopropane-1-carboxylic acid→methyl 1-((2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→lithium 1-((2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide
dimethyl cyclopropane-1,1-dicarboxylate→1-(methoxycarbonyl)cyclopropane-1-carboxylic acid→methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate→1-(4-hydroxy-3-methoxyphenyl)ethan-1-one→methyl 1-((4-acetyl-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-2-methoxy-5-nitrophenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-5-amino-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-hydroxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→4-fluoro-2-methyl-1H-indol-5-ol→methyl 1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylic acid→benzyl (1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamate
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