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CAS 1146629-75-5
(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
Codes: RUXO-007
Application context (from source-drug indications)
Atopic dermatitisRuxolitinib PhosphateVitiligoRuxolitinib PhosphateGraft-versus-host diseaseRuxolitinib PhosphateMyelofibrosisRuxolitinib PhosphatePolycythaemia veraRuxolitinib Phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ruxolitinib Phosphate | Tier A — Act now | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-chloro-7H-pyrrolo[2,3-d]pyrimidine→(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→(4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→3-cyclopentylpropiolonitrile→(Z)-(4-(1-(2-cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(Z)-(4-(1-(3-amino-1-cyclopentyl-3-oxoprop-1-en-1-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(3-amino-1-cyclopentyl-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates | On request | On request | On request | — |
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