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CAS 116-11-0
2-Methoxy-1-propene2-methoxyprop-1-ene
Codes: 101438-11-b, (XXXIII)101438-35-b,(XXXIII)101438-35-c, (V)101438-39-a, (IV)140605-27-a, LAND-002, FULV-017
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateBladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Pancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelNon-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）Supraventricular tachycardiaLandiolol Hydrochloride室性心律失常Landiolol HydrochlorideArrhythmiaLandiolol Hydrochloride窦性心动过速Landiolol HydrochlorideAtrial fibrillationLandiolol HydrochlorideAtrial flutterLandiolol HydrochlorideBreast cancerFulvestrantProstate cancerFulvestrant多发性骨纤维性发育不良Fulvestrant性早熟FulvestrantHR阳性乳腺癌FulvestrantMetastatic breast cancerFulvestrant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
| Landiolol Hydrochloride | Tier C — Watch / trade | - |
| Fulvestrant | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-7,10-dihydroxy-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-diene-8-carboxylate→(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione→methyl 3-[(1S,5S,6R,9S,10S,12R,15S)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-3,7-dioxo-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-en-9-yl]propanoate→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-10-(prop-1-en-2-yloxy)-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-hydroxy-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl 4-methylbenzene-1-sulfonate→(1S,5S,6S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-3-one→(1S,5S,6R,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-8-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(3aS,5S,8S,9aR,10S,12S,13aS,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxy-6,9a,14,14-tetramethyl-13-methylidene-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-3-one→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3-oxo-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-15-hydroxy-13,17,20,20-tetramethyl-3-oxo-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→2-Methoxy-1-propene
(1S,5S,7R,10S,12S,16S)-12-(benzyloxy)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6(11),14-diene-7,10-diol→(1S,5S,7R,10S,12S,16S)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6(11),14-diene-7,10,12-triol→(2S,6S,8S,12S,16S,19R)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,21,21-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicosa-1(20),9-dien-19-ol→(1R,2S,6S,8S,12S,14S,16S,19R,21S)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,22,22-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silahexacyclo[10.7.2.1(6,10).0(1,21).0(2,6).0(16,21)]docos-9-en-19-ol→(1S,3S,5S,6R,10S,11S,12S,16S)-10,12,16-trihydroxy-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-7-one→(1S,2S,6S,8S,12S,14S,16S,21S)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,22,22-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silahexacyclo[10.7.2.1(6,10).0(1,21).0(2,6).0(16,21)]docos-9-en-19-one→(1S,2S,3S,5S,9S,13S,18S)-5-[(tert-butyldimethylsilyl)oxy]-2,3-dihydroxy-6,19,19-trimethyl-10,12-dioxapentacyclo[7.7.2.1(3,7).0(1,18).0(13,18)]nonadec-6-ene-11,16-dione→(1S,2S,4S,6S,8S,12S,13S,14S)-8-[(tert-butyldimethylsilyl)oxy]-12,14-dihydroxy-9,19,19-trimethyl-4-phenyl-3,5-dioxapentacyclo[11.4.1.1(6,10).0(1,13).0(2,6)]nonadec-9-en-17-one→(1S,3S,5S,10S,11S,12S,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,14-diene-7,10,12-triol→(1R,2S,4S,6S,8S,12S,16S,20S)-8-hydroxy-9,20,21,21-tetramethyl-4,14-diphenyl-3,5,13,15-tetraoxa-14-borapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicos-9-en-19-one→(1R,2S,4S,6S,8S,12S,16S,20S)-8-[(tert-butyldimethylsilyl)oxy]-9,20,21,21-tetramethyl-4,14-diphenyl-3,5,13,15-tetraoxa-14-borapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicos-9-en-19-one→(1S,3S,5S,6R,10S,11S,12S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10,12-dihydroxy-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-7-one→2-Methoxy-1-propene→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-7,12-dione→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-7-yl trifluoromethanesulfonate
(1S,3S,5S,6R,7S,8S,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-7-hydroxy-7-(hydroxymethyl)-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→(1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-12-[(2-methoxypropan-2-yl)oxy]-13,17,20,20-tetramethyl-14-oxo-3-phenyl-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-14-oxo-3-phenyl-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-15-(acetyloxy)-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,13-dihydroxy-9-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→2-Methoxy-1-propene→(1S,3S,5S,6S,8S,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-7-yl trifluoromethanesulfonate→(1S,3S,5S,6S,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-12-one→(1S,3S,5S,6S,8S,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-12-one→(1S,3S,5S,6S,8S,10S,11S,13S,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate
(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→chloro(prop-2-yn-1-yloxy)methanone→(2R,3S)-2-hydroxy-3-phenyl-3-{[(prop-2-yn-1-yloxy)carbonyl]amino}propanoic acid→methyl (2R,3S)-2-hydroxy-3-phenyl-3-{[(prop-2-yn-1-yloxy)carbonyl]amino}propanoate→5-(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-2-(benzoyloxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl 3-prop-2-yn-1-yl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→2-Methoxy-1-propene→5-methyl 3-prop-2-yn-1-yl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→(4S,5R)-2,2-dimethyl-4-phenyl-3-[(prop-2-yn-1-yloxy)carbonyl]-1,3-oxazolidine-5-carboxylic acid→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,13-dihydroxy-9-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-{[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→alpha-Chlorobenzaldehyde→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetyloxy)-1,4-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
Isopropyl (2E)-3-phenylacrylate→1,1-Dimethylethyl carbamate→Isopropyl (2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate→2-Methoxy-1-propene→3-tert-Butyl 5-isopropyl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid
methyl (1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-7,10-dihydroxy-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-diene-8-carboxylate→(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione→methyl 3-[(1S,5S,6R,9S,10S,12R,15S)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-3,7-dioxo-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-en-9-yl]propanoate→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-10-(prop-1-en-2-yloxy)-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-hydroxy-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl 4-methylbenzene-1-sulfonate→(1S,5S,6S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-3-one→(1S,5S,6R,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-8-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(3aS,5S,8S,9aR,10S,12S,13aS,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxy-6,9a,14,14-tetramethyl-13-methylidene-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-3-one→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3-oxo-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-15-hydroxy-13,17,20,20-tetramethyl-3-oxo-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→2-Methoxy-1-propene
(1S,5S,7R,10S,12S,16S)-12-(benzyloxy)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6(11),14-diene-7,10-diol→(1S,5S,7R,10S,12S,16S)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6(11),14-diene-7,10,12-triol→(2S,6S,8S,12S,16S,19R)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,21,21-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicosa-1(20),9-dien-19-ol→(1R,2S,6S,8S,12S,14S,16S,19R,21S)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,22,22-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silahexacyclo[10.7.2.1(6,10).0(1,21).0(2,6).0(16,21)]docos-9-en-19-ol→(1S,3S,5S,6R,10S,11S,12S,16S)-10,12,16-trihydroxy-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-7-one→(1S,2S,6S,8S,12S,14S,16S,21S)-4,4-di-tert-butyl-8-[(tert-butyldimethylsilyl)oxy]-9,22,22-trimethyl-14-phenyl-3,5,13,15-tetraoxa-4-silahexacyclo[10.7.2.1(6,10).0(1,21).0(2,6).0(16,21)]docos-9-en-19-one→(1S,2S,3S,5S,9S,13S,18S)-5-[(tert-butyldimethylsilyl)oxy]-2,3-dihydroxy-6,19,19-trimethyl-10,12-dioxapentacyclo[7.7.2.1(3,7).0(1,18).0(13,18)]nonadec-6-ene-11,16-dione→(1S,2S,4S,6S,8S,12S,13S,14S)-8-[(tert-butyldimethylsilyl)oxy]-12,14-dihydroxy-9,19,19-trimethyl-4-phenyl-3,5-dioxapentacyclo[11.4.1.1(6,10).0(1,13).0(2,6)]nonadec-9-en-17-one→(1S,3S,5S,10S,11S,12S,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,14-diene-7,10,12-triol→(1R,2S,4S,6S,8S,12S,16S,20S)-8-hydroxy-9,20,21,21-tetramethyl-4,14-diphenyl-3,5,13,15-tetraoxa-14-borapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicos-9-en-19-one→(1R,2S,4S,6S,8S,12S,16S,20S)-8-[(tert-butyldimethylsilyl)oxy]-9,20,21,21-tetramethyl-4,14-diphenyl-3,5,13,15-tetraoxa-14-borapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicos-9-en-19-one→(1S,3S,5S,6R,10S,11S,12S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10,12-dihydroxy-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-7-one→2-Methoxy-1-propene→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-7,12-dione→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-7-yl trifluoromethanesulfonate
(1S,3S,5S,6R,7S,8S,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-7-hydroxy-7-(hydroxymethyl)-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→(1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-12-[(2-methoxypropan-2-yl)oxy]-13,17,20,20-tetramethyl-14-oxo-3-phenyl-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-14-oxo-3-phenyl-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-15-(acetyloxy)-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,13-dihydroxy-9-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→2-Methoxy-1-propene→(1S,3S,5S,6S,8S,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→(1S,3S,5S,6R,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-7-yl trifluoromethanesulfonate→(1S,3S,5S,6S,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-12-one→(1S,3S,5S,6S,8S,10S,11S,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-12-one→(1S,3S,5S,6S,8S,10S,11S,13S,16S)-16-[(tert-butyldimethylsilyl)oxy]-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-12-oxo-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate
(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→chloro(prop-2-yn-1-yloxy)methanone→(2R,3S)-2-hydroxy-3-phenyl-3-{[(prop-2-yn-1-yloxy)carbonyl]amino}propanoic acid→methyl (2R,3S)-2-hydroxy-3-phenyl-3-{[(prop-2-yn-1-yloxy)carbonyl]amino}propanoate→5-(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-2-(benzoyloxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl 3-prop-2-yn-1-yl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→2-Methoxy-1-propene→5-methyl 3-prop-2-yn-1-yl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→(4S,5R)-2,2-dimethyl-4-phenyl-3-[(prop-2-yn-1-yloxy)carbonyl]-1,3-oxazolidine-5-carboxylic acid→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,13-dihydroxy-9-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-15-{[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→alpha-Chlorobenzaldehyde→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetyloxy)-1,4-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-9-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
Isopropyl (2E)-3-phenylacrylate→1,1-Dimethylethyl carbamate→Isopropyl (2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate→2-Methoxy-1-propene→3-tert-Butyl 5-isopropyl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid
(S)-3-chloropropane-1,2-diol→2-methoxyprop-1-ene→(S)-4-(chloromethyl)-2,2-dimethyl-1,3-dioxolane→3-(4-hydroxyphenyl)propanoic acid→(S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-hydroxyphenyl)propanoate→(S)-2-(bromomethyl)oxirane→((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-(((S)-oxiran-2-yl)methoxy)phenyl)propanoate→N-(2-aminoethyl)morpholine-4-carboxamide
(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol→(8R,9S,10R,13S,14S,17S)-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one→(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one→2-methoxyprop-1-ene→(8R,9S,13S,14S,17S)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one→1,9-dibromononane→(7S,8R,9S,13S,14S,17S)-7-(9-bromononyl)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one→(7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene→4,4,5,5,5-pentafluoropentyl carbamimidothioate methanesulfonate→(9-((7R,8R,9S,13S,14S,17S)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)nonyl)(4,4,5,5,5-pentafluoropentyl)sulfane
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