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CAS 117049-14-6
tert-Butyl [(1S)-2-hydroxy-1-phenylethyl]carbamate
Codes: (II)140605-15-a
Application context (from source-drug indications)
Bladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Non-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-(+)-2-Phenylglycine→tert-Butyl [(1S)-2-hydroxy-1-phenylethyl]carbamate→tert-Butyl [(1S)-2-cyano-2-hydroxy-1-phenylethyl]carbamate→Methyl (3S)-3-amino-2-hydroxy-3-phenylpropanoate hydrogen chloride (1/1)→Phosgene→Bis(1,1-dimethylethyl) dicarbonoate→3-tert-Butyl 5-methyl (4S,5R)-2-oxo-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→1-(Dimethoxymethyl)-4-methoxybenzene→(X)140605-15-a→(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
(S)-(+)-2-Phenylglycine→tert-Butyl [(1S)-2-hydroxy-1-phenylethyl]carbamate→tert-Butyl [(1S)-2-cyano-2-hydroxy-1-phenylethyl]carbamate→Methyl (3S)-3-amino-2-hydroxy-3-phenylpropanoate hydrogen chloride (1/1)→Carbon oxychloride→Bis(1,1-dimethylethyl) dicarbonoate→3-tert-Butyl 5-methyl (4S,5R)-2-oxo-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→1-(Dimethoxymethyl)-4-methoxybenzene→(X)140605-15-a→(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
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