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CAS 1170661-05-8
((2R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate
Codes: CENSA-017
Application context (from source-drug indications)
进行性核上性麻痹CensavudineFrontotemporal dementiaCensavudineAmyotrophic lateral sclerosisCensavudineAicardi综合征CensavudineHIV infectionCensavudine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Censavudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
furan-2-ylmethanol→5-oxo-5,6-dihydro-2H-pyran-2-yl acetate→(S)-5-oxo-5,6-dihydro-2H-pyran-2-yl acetate→(2S,5S)-5-hydroxy-5-((trimethylsilyl)ethynyl)-5,6-dihydro-2H-pyran-2-yl acetate→(5R)-5-(hydroxymethyl)-5-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-ol→((2R)-5-acetoxy-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate→5-methylpyrimidine-2,4(1H,3H)-dione→((2R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate→1-((5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
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