CAS 1171331-39-7

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Codes: (XII)700647-1-a,(XII)700647-1-b, (IX)700647-3-a, (V)700647-4-a

Application context (from source-drug indications)

蠕形螨性睑缘炎Lotilaner螨虫感染Lotilaner莱姆病LotilanerRosaceaLotilaner睑板腺功能障碍Lotilaner

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Lotilaner	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LotilanerOptimised routesteps: 8total yield: /

4-Methylthiophene-2-carboxylic acid→N-Methoxy-N,4-dimethylthiophene-2-carboxamide→Bromo(methyl)magnesium→1-(4-Methylthiophen-2-yl)ethan-1-one→3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole→1-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one→2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-en-1-one→Amino alcohol hydrochloride→3-Methyl-5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→3-Methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→5-Bromo-1,2,3-trichlorobenzene→(3,4,5-Trichlorophenyl)magnesium bromide→2,2,2-Trifluoro-N,N-dimethylacetamide

LotilanerOptimised routesteps: 3total yield: /

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→2,5-Dioxo-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester→2-(Benzyloxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→2-Amino-1,1,1-trifluoroethane hydrochloride→2-Amino-1,1,1-trifluoroethane→Benzyl [2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate→[(2,2,2-Trifluoroethylcarbamoyl)methyl]carbamic acid tert-butyl ester→2-Chloranylethanoyl chloride→2-Chloro-N-(2,2,2-trifluoroethyl)acetamide→(N-Benzylaminomethyl)benzene→2-(Dibenzylamino)-N-(2,2,2-trifluoroethyl)acetamide

LotilanerOptimised routesteps: 6total yield: /

2-Formyl-3-methylthiophene→5-Bromo-3-methylthiophene-2-carbaldehyde→5-Bromo-3-methylthiophene-2-carboxylic acid→Nitrocarbol→3-Methyl-5-(nitromethyl)thiophene-2-carboxylic acid→5-Carboxy-4-methylthiophene-2-carbonitrile oxide→1,2,3-Trichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene→3-Methyl-5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

LotilanerOptimised routesteps: 4total yield: /

2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-en-1-one→3-Methyl-5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]thiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→3-Methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]thiophene-2-carboxamide→Amine N-oxide

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.