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CAS 118-92-3

Anthranilic acid2-Aminobenzoic acid

Codes: Ambroxol- 018

Application context (from source-drug indications)

Chronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Roxithromycin/Ambroxol HydrochlorideTier C — Watch / trade-
Ambroxol HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 10total yield: 2.345g(Ambroxol)
Anthranilic acid→Methyl anthranilate→Methyl 2-amino-3,5-dibromobenzoate→2-Amino-3,5-dibromobenzyl alcohol→2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine→2-Amino-3,5-dibromobenzaldehyde→trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol→trans-4-Aminocyclohexanol
Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 3total yield: 10.9g(Ambroxol- 037)
2-Benzofuran-1,3-dione→Isourea→Phthalimide→3,5-Dibromo-2-aminobenzoic acid→2-Aminobenzoic acid
Ambroxol HydrochlorideOptimised routesteps: 10total yield: 2.345g(Ambroxol)
Anthranilic acid→Methyl anthranilate→Methyl 2-amino-3,5-dibromobenzoate→2-Amino-3,5-dibromobenzyl alcohol→2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine→2-Amino-3,5-dibromobenzaldehyde→trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol→trans-4-Aminocyclohexanol
Ambroxol HydrochlorideOptimised routesteps: 3total yield: 10.9g(Ambroxol- 037)
2-Benzofuran-1,3-dione→Isourea→Phthalimide→3,5-Dibromo-2-aminobenzoic acid→2-Aminobenzoic acid

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.