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CAS 1193314-69-0
5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
Codes: CIPARG-035
Application context (from source-drug indications)
Falciparum malariaCipargaminPlasmodium infectionCipargamin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cipargamin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-chloroindoline-2,3-dione→6-chloro-5-fluoro-1H-indole→6-chloro-5-fluoro-1H-indole-3-carbaldehyde→(Z)-6-chloro-5-fluoro-3-(2-nitroprop-1-en-1-yl)-1H-indole→1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-amine→5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one→(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
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