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CAS 1194-02-1

4-fluorobenzonitrile

Codes: CRISA-008, PIOG-009

Application context (from source-drug indications)

Atopic dermatitisCrisaboroleDermatitisCrisaboroleEczemaCrisaboroleAlopecia areataCrisaboroleLocalised sclerodermaCrisaborolePlaque psoriasisCrisaboroleType 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
CrisaboroleTier C — Watch / trade-
Alogliptin Benzoate/Pioglitazone HydrochlorideTier C — Watch / trade-
Pioglitazone HydrochlorideTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

CrisaboroleOptimised routesteps: 2total yield: /
4-(4-bromo-3-formylphenoxy)benzonitrile→2-bromo-5-hydroxybenzaldehyde→ethane-1,2-diol→4-bromo-3-(1,3-dioxolan-2-yl)phenol→4-fluorobenzonitrile
Alogliptin Benzoate/Pioglitazone HydrochlorideOptimised routesteps: 4total yield: 0.65 g
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-fluorobenzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Pioglitazone HydrochlorideOptimised routesteps: 4total yield: 0.65 g
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-fluorobenzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Taizhou GMP-like Site2-BROMO-5-HYDROXYBENZALDEHYDE
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works4-(4-Bromo-3-formyl-phenoxy)-benzonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site4-[4-bromo-3-(hydroxymethyl)phenoxy]benzonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site[2-bromo-5-(4-cyanophenoxy)phenyl]methyl acetate
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.