CAS 1197953-49-3

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Codes: (XI)909096-1-a,(XI)909096-1-b, (VII)909096-2-a

Application context (from source-drug indications)

Non-small cell lung cancerIruplinalkib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Iruplinalkib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

IruplinalkibOptimised routesteps: 9total yield: /

1-(Phenylmethyl)-4-piperidinone→3-Ethoxy-3-oxopropanenitrile→2,4-Dioxo-9-(phenylmethyl)-3,9-diazaspiro[5.5]undecane-1,5-dicarbonitrile→1'-Benzylspiro[3,7-diazabicyclo[3.3.1]nonane-9,4'-piperidine]-2,4,6,8-tetrone→9-(Phenylmethyl)-3,9-diazaspiro[5.5]undecane-2,4-dione→3-Benzyl-3,9-diazaspiro[5.5]undecane→3-Boc-3,9-diazaspiro[5.5]undecane→4-Fluoro-2-methoxy-1-nitrobenzene→tert-Butyl 9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate→tert-Butyl 9-(4-amino-3-methoxyphenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate→(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide→5-Chloro-N2-[4-(3,9-diazaspiro[5.5]undecan-3-yl)-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine→Formaldehyde

IruplinalkibOptimised routesteps: 3total yield: /

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide→1-Ethoxyphosphonoyloxy ethane→2,4,5-Trichloropyrimidine→Bromo(methyl)magnesium→Dimethyl(oxo)phosphanium→2-Aminophenyl iodide→(2-Aminophenyl)dimethylphosphine oxide

IruplinalkibOptimised routesteps: 4total yield: /

3-Benzyl-3,9-diazaspiro[5.5]undecane→4-Fluoro-2-methoxy-1-nitrobenzene→3-Benzyl-9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane→Iodomethane→3-Benzyl-9-(3-methoxy-4-nitrophenyl)-3-methyl-3,9-diazaspiro[5.5]undecan-3-ium iodide→2-Methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undec-3-yl)benzenamine→(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide→tert-Butyl 9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate→3-(3-Methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane→Formaldehyde→3-(3-Methoxy-4-nitrophenyl)-9-methyl-3,9-diazaspiro[5.5]undecane

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl] -4-pyrimidinamine Pharmaceutical Intermediates	On request	On request	On request	—

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