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CAS 120-57-0
benzo[d][1,3]dioxole-5-carbaldehyde
Codes: TADA-002
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinErectile dysfunctionAmlodipine Besylate/TadalafilHypertensionAmlodipine Besylate/TadalafilBenign prostatic hyperplasiaTadalafilPulmonary hypertensionTadalafilPulmonary arterial hypertensionTadalafilErectile dysfunctionTadalafilPremature ejaculationTadalafilGenitourinary neoplasmTadalafil
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Amlodipine Besylate/Tadalafil | Tier C — Watch / trade | - |
| Tadalafil | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→tryptophanoyl chloride hydrochloride→methyl 2-(methyl-l2-azaneyl)acetate hydrochloride→methyl N-methyl-N-tryptophylglycinate hydrochloride→methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate
benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→tryptophanoyl chloride hydrochloride→methyl 2-(methyl-l2-azaneyl)acetate hydrochloride→methyl N-methyl-N-tryptophylglycinate hydrochloride→methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate
benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate→methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→tryptophanoyl chloride hydrochloride→methyl 2-(methyl-l2-azaneyl)acetate hydrochloride→methyl N-methyl-N-tryptophylglycinate hydrochloride→methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate
benzo[d][1,3]dioxole-5-carbaldehyde→(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride→D-tryptophan
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