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CAS 1203579-66-1
3-Chloro-4-hydroxy-7-methoxyquinoline
Codes: (II)1078735-2-a
Application context (from source-drug indications)
Breast cancerImlunestrant TosylateMetastatic breast cancerImlunestrant TosylateMetastatic cancerImlunestrant TosylateOvarian cancerImlunestrant TosylateEndometrial cancerImlunestrant TosylateColorectal cancerImlunestrant Tosylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Imlunestrant Tosylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Hydroxy-7-methoxyquinoline→3-Chloro-4-hydroxy-7-methoxyquinoline→4-Bromo-3-chloro-7-methoxyquinoline→(4-Fluorophenyl)methanone→(3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone→4-Fluoranylbenzoyl chloride→(3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone→1,1-Diethoxy-2-hydroxyethane→(3-Chloro-7-hydroxyquinolin-4-yl)[4-(2,2-diethoxyethoxy)phenyl]methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→[4-(2,2-Diethoxyethoxy)phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→(4-Fluorophenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[(R)-[4-(2,2-Diethoxyethoxy)phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→(5R)-5-[4-(2,2-Diethoxyethoxy)phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol
Intermediates available on this site
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