CAS 1207947-49-6

(2S,5R)-benzyl 5-amino-2-methylpiperidine-1-carboxylate

Codes: PF-06651600-006

Application context (from source-drug indications)

Alopecia areataRitlecitinib tosylateVitiligoRitlecitinib tosylateChronic urticariaRitlecitinib tosylateHidradenitis suppurativaRitlecitinib tosylate瘢痕疙瘩Ritlecitinib tosylate乳糜泻Ritlecitinib tosylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ritlecitinib tosylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ritlecitinib tosylateOriginator routesteps: 9total yield: /

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one→6-methylpyridin-3-amine→tert-butyl (6-methylpyridin-3-yl)carbamate→tert-butyl (6-methylpiperidin-3-yl)carbamate→benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate→(2S,5R)-benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate→(2S,5R)-benzyl 5-amino-2-methylpiperidine-1-carboxylate→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→(2S,5R)-benzyl 5-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidine-1-carboxylate→N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride→1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester Pharmaceutical Intermediates	On request	On request	On request	—

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