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CAS 1210039-33-0
(4aS,4bR,7aS,8aR)-2-(4-methoxyphenyl)hexahydrofuro[3',2':3,4]cyclopenta[1,2-d][1,3]dioxin-6(4H)-one
Codes: LUBI-051
Application context (from source-drug indications)
ConstipationLubiprostoneOpioid-induced constipationLubiprostoneChronic idiopathic constipationLubiprostoneDrug-related adverse effects and reactionsLubiprostoneNon-alcoholic steatohepatitisLubiprostonePeritoneal cancerLubiprostone
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lubiprostone | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate→(5-carboxypentyl)triphenylphosphonium bromide→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→benzyl (Z)-7-((1R,2S,3R,5S)-5-hydroxy-2-(hydroxymethyl)-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoate→benzyl (Z)-7-((1R,2R,3R)-2-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-3-((4-methoxybenzyl)oxy)-5-oxocyclopentyl)hept-5-enoate→(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate→1-(dimethoxymethyl)-4-methoxybenzene→(4aS,4bR,7aS,8aR)-2-(4-methoxyphenyl)hexahydrofuro[3',2':3,4]cyclopenta[1,2-d][1,3]dioxin-6(4H)-one→(3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol→(Z)-7-((1R,2S,3R,5S)-5-hydroxy-2-(hydroxymethyl)-3-((4-methoxybenzyl)oxy)cyclopentyl)hept-5-enoic acid→benzyl (Z)-7-((1R,2R,3R)-2-formyl-3-((4-methoxybenzyl)oxy)-5-oxocyclopentyl)hept-5-enoate
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