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CAS 1229236-83-2
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone
Codes: GAND-006
Application context (from source-drug indications)
Haematological malignancyGandotinibMyelofibrosisGandotinibMyeloproliferative neoplasmGandotinibEssential thrombocythaemiaGandotinibPolycythaemia veraGandotinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Gandotinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-chloropyridazin-3-amine→1,1-dimethoxy-N,N-dimethylethanamine→(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide→2-chloro-1-(4-chloro-2-fluorophenyl)ethanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone→4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine→1-(tert-butyl)-3-methyl-1H-pyrazol-5-amine→3-(4-chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine→1-(4-chloro-2-fluorophenyl)ethanone→tert-butylhydrazine hydrochloride→(E)-3-aminobut-2-enenitrile→3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide→2-chloro-1-(4-chloro-2-fluorophenyl)ethanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanone→(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone→4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine→2-(1,3-dioxoisoindolin-2-yl)acetic acid→2-((6-chloro-3-(4-chloro-2-fluorobenzoyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)isoindoline-1,3-dione→(8-(aminomethyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)(4-chloro-2-fluorophenyl)methanone→1-bromo-2-(2-bromoethoxy)ethane→(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol→1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-amine→3-(4-chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine→tert-butyl hydrazinecarboxylate→4-methoxybenzaldehyde→tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate→tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate→(4-methoxybenzyl)hydrazine→3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
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