← Back to patent-cliff list
CAS 123-08-0
4-hydroxybenzaldehyde4-Formylphenol4-Hydroxybenzaldehyde
Codes: PIMAV-001, Tamsulosin Hydrochloride-022, SAFI-002, BAZE-010, PIOG-015, Bisoprolol-015, FEBU-016
Application context (from source-drug indications)
DelusionPimavanserin TartrateHallucinationPimavanserin TartrateErectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinParkinson's diseaseSafinamide MesylatePainSafinamide MesylateDrug-induced dyskinesiaSafinamide MesylateHepatic function declineSafinamide MesylateMultiple system atrophySafinamide MesylateRenal impairmentSafinamide MesylateLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideOestrogen deficiency syndromeConjugated Estrogens/Bazedoxifene AcetateOsteoporosisConjugated Estrogens/Bazedoxifene AcetateVasomotor symptomsConjugated Estrogens/Bazedoxifene AcetateNon-invasive ductal carcinomaConjugated Estrogens/Bazedoxifene AcetateAnxietyConjugated Estrogens/Bazedoxifene AcetateMenopausal symptomsConjugated Estrogens/Bazedoxifene AcetateType 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideHypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumarateHyperuricaemiaFebuxostatGoutFebuxostatIntracranial haemorrhageFebuxostatUlcerative colitisFebuxostatChronic renal impairmentFebuxostatPainFebuxostatBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin HydrochloridePostmenopausal osteoporosisBazedoxifene AcetateBreast cancerBazedoxifene AcetateOsteoporosisBazedoxifene AcetateMenopausal symptomsBazedoxifene AcetateType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone HydrochlorideHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol Fumarate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pimavanserin Tartrate | Tier C — Watch / trade | 2029 |
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Safinamide Mesylate | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Conjugated Estrogens/Bazedoxifene Acetate | Tier C — Watch / trade | - |
| Alogliptin Benzoate/Pioglitazone Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Amlodipine Besylate/Bisoprolol Fumarate | Tier C — Watch / trade | - |
| Febuxostat | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Bazedoxifene Acetate | Tier C — Watch / trade | - |
| Pioglitazone Hydrochloride | Tier B — Position early | - |
| Bisoprolol Fumarate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-hydroxybenzaldehyde→1-bromo-2-methylpropane→4-isobutoxybenzaldehyde→(E)-4-isobutoxybenzaldehyde oxime→(4-isobutoxyphenyl)methanamine→1-isobutoxy-4-(isocyanatomethyl)benzene→N-(4-fluorobenzyl)-1-methylpiperidin-4-amine→1-methylpiperidin-4-one→(4-fluorophenyl)methanamine→sodium triacetoxyhydroborate
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 4total yield: 18g(Tamsulosin Hydrochloride (API))
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→1-(2-chloroethyl)azepane hydrochloride→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→(4-(2-(azepan-1-yl)ethoxy)phenyl)methanol→1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride
1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→azepane→1,2-dibromoethane→1-(2-bromoethyl)azepane→4-(benzyloxy)aniline→N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline
thiazolidine-2,4-dione→4-hydroxybenzaldehyde→5-ethyl-2-vinylpyridine→2-bromo-1-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzylidene)thiazolidine-2,4-dione→5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione→5-(4-(2-chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
2-(5-ethylpyridin-2-yl)ethan-1-ol→thiazolidine-2,4-dione→4-hydroxybenzaldehyde→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→5-ethyl-2-(2-hydroxyethyl)pyridine 1-oxide→1-(5-ethylpyridin-2-yl)ethane-1,2-diyl diacetate→1-(5-ethylpyridin-2-yl)ethane-1,2-diol→4-(5-ethylpyridin-2-yl)-1,3,2-dioxathiolane 2-oxide→1-(5-ethylpyridin-2-yl)-2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate→(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate→2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate
Dutasteride/Tamsulosin HydrochlorideOptimised routesteps: 4total yield: 18g(Tamsulosin Hydrochloride (API))
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
4-Formylphenyl acetate→4-(Acetyloxy)benzenemethanol→4-[(2-Isopropoxyethoxy)methyl]phenyl acetate→Bisoprolol-025→4-Hydroxybenzaldehyde→Isopropylglycol
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→4-hydroxybenzaldehyde→4-isobutoxybenzaldehyde→3-bromo-4-isobutoxybenzaldehyde→(E)-3-bromo-4-isobutoxybenzaldehyde oxime→3-bromo-4-isobutoxybenzonitrile→3-bromo-4-isobutoxybenzothioamide→ethyl 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→ethyl 2-chloro-3-oxobutanoate→1-bromo-2-methylpropane
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→1-(2-chloroethyl)azepane hydrochloride→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→(4-(2-(azepan-1-yl)ethoxy)phenyl)methanol→1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride
1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→azepane→1,2-dibromoethane→1-(2-bromoethyl)azepane→4-(benzyloxy)aniline→N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline
thiazolidine-2,4-dione→4-hydroxybenzaldehyde→5-ethyl-2-vinylpyridine→2-bromo-1-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzylidene)thiazolidine-2,4-dione→5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione→5-(4-(2-chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
2-(5-ethylpyridin-2-yl)ethan-1-ol→thiazolidine-2,4-dione→4-hydroxybenzaldehyde→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→5-ethyl-2-(2-hydroxyethyl)pyridine 1-oxide→1-(5-ethylpyridin-2-yl)ethane-1,2-diyl diacetate→1-(5-ethylpyridin-2-yl)ethane-1,2-diol→4-(5-ethylpyridin-2-yl)-1,3,2-dioxathiolane 2-oxide→1-(5-ethylpyridin-2-yl)-2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate→(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate→2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
4-Formylphenyl acetate→4-(Acetyloxy)benzenemethanol→4-[(2-Isopropoxyethoxy)methyl]phenyl acetate→Bisoprolol-025→4-Hydroxybenzaldehyde→Isopropylglycol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.