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CAS 1257874-84-2
(S)-N-(1-hydroxypentan-2-yl)formamide
Codes: TELAP-029
Application context (from source-drug indications)
Hepatitis CTelaprevirChronic hepatitis CTelaprevirHIV infectionTelaprevirHepatic function declineTelaprevirOpioid dependenceTelaprevirKidney diseaseTelaprevir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Telaprevir | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
pyrazine-2-carboxylic acid→methyl (S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate→(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid→(S)-2-aminopentan-1-ol→(S)-N-(1-hydroxypentan-2-yl)formamide→(S)-N-(1-oxopentan-2-yl)formamide→isocyanocyclopropane→(3S)-1-(cyclopropylamino)-3-formamido-1-oxohexan-2-yl acetate→(3S)-1-(cyclopropylamino)-3-isocyano-1-oxohexan-2-yl acetate→(3aS,6aR)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole→(3S)-3-((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamido)-1-(cyclopropylamino)-1-oxohexan-2-yl acetate→methyl (S)-2-amino-2-cyclohexylacetate→methyl (S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetate→(S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetic acid→methyl (S)-2-amino-3,3-dimethylbutanoate
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