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CAS 1258501-18-6
6beta,7beta:15beta,16beta-Dimethylene-3beta-t-butyldimethylsilyloxy-5beta,17beta-dihydroxy-17alpha-(2-ethoxycarbonyl)-ethyl-androstane
Codes: (XVII)169995-1-b
Application context (from source-drug indications)
ContraceptionDrospirenoneStomatitis, aphthousDrospirenonePremenstrual dysphoric disorderDrospirenonePremenstrual syndromeDrospirenoneDysmenorrhoeaDrospirenoneDepressionDrospirenone
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Drospirenone | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R,2R,4R,5R,10R,11S,14S,15S,16S,18S,19S)-5-Hydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5',7-dione→3-[3beta-[tert-Butyl(dimethyl)silyloxy]-5beta,17beta-dihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl]-2-propynoic acid ethyl ester→6beta,7beta:15beta,16beta-Dimethylene-3beta-t-butyldimethylsilyloxy-5beta,17beta-dihydroxy-17alpha-(2-ethoxycarbonyl)-ethyl-androstane→(2R,4R,5R,7S,10R,14S,15S,16S,18S)-5,7-Dihydroxy-10,14-dimethylspiro[hexacyclo[9.8.0.0(2,4).0(5,10).0(14,19).0(16,18)]nonadecane-15,2'-oxolane]-5'-one
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