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CAS 128-08-5
1-bromopyrrolidine-2,5-dione
Codes: ALPE-015, LENA-002
Application context (from source-drug indications)
Growth disorderAlpelisibGenetic diseaseAlpelisibPIK3CA-related overgrowth spectrumAlpelisibBreast cancerAlpelisibMarginal zone B-cell lymphomaLenalidomideFollicular lymphomaLenalidomideAdult T-cell leukaemia/lymphomaLenalidomideMantle cell lymphomaLenalidomideMyelodysplastic syndromeLenalidomideMultiple myelomaLenalidomide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Alpelisib | Tier C — Watch / trade | 2029 |
| Lenalidomide | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine→(S)-pyrrolidine-2-carboxamide→4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine→N-methoxy-N-methylacetamide→1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one→1-bromopyrrolidine-2,5-dione→4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine hydrobromide→phenyl (4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)carbamate
methyl 2-methyl-3-nitrobenzoate→1-bromopyrrolidine-2,5-dione→methyl 2-(bromomethyl)-3-nitrobenzoate→(tert-butoxycarbonyl)-L-glutamine→(R)-2-((tert-butoxycarbonyl)amino)-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→(R)-2-amino-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | methyl 2-(bromomethyl)-3-nitrobenzoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 3-aminopiperidine-2,6-dione hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.