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CAS 130158-22-4
Ethyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-iodobutanoate
Codes: Atorvastatin-108
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-4-Chloro-3-hydroxybutanoic acid ethyl ester→Ethyl (3S)-3-hydroxy-4-iodobutanoate→Ethyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-iodobutanoate→Ethyl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]hex-5-enoate→Chlorido(ethenyl)magnesium<-fgf->Chloro(vinyl)magnesium<-fgf->Vinylmagnesium chloride
(S)-4-Chloro-3-hydroxybutanoic acid ethyl ester→Ethyl (3S)-3-hydroxy-4-iodobutanoate→Ethyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-iodobutanoate→Ethyl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]hex-5-enoate→Chlorido(ethenyl)magnesium<-fgf->Chloro(vinyl)magnesium<-fgf->Vinylmagnesium chloride
Intermediates available on this site
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